Structural properties and anticoagulant/cytotoxic activities of heterochiral enantiomeric thrombin binding aptamer (TBA) derivatives

The thrombin binding aptamer (TBA) possesses promising antiproliferative properties. However, its development as an anticancer agent is drastically impaired by its concomitant anticoagulant activity. Therefore, suitable chemical modifications in the TBA sequence would be required in order to preserv...

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Detalles Bibliográficos
Publicado en:Nucleic Acids Res
Autores principales: Virgilio, Antonella, Esposito, Veronica, Pecoraro, Annalisa, Russo, Annapina, Vellecco, Valentina, Pepe, Antonietta, Bucci, Mariarosaria, Russo, Giulia, Galeone, Aldo
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2020
Materias:
Chemical Biology and Nucleic Acid Chemistry
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7736819/
https://ncbi.nlm.nih.gov/pubmed/33270863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa1109
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