Structural properties and anticoagulant/cytotoxic activities of heterochiral enantiomeric thrombin binding aptamer (TBA) derivatives

The thrombin binding aptamer (TBA) possesses promising antiproliferative properties. However, its development as an anticancer agent is drastically impaired by its concomitant anticoagulant activity. Therefore, suitable chemical modifications in the TBA sequence would be required in order to preserv...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Virgilio, Antonella, Esposito, Veronica, Pecoraro, Annalisa, Russo, Annapina, Vellecco, Valentina, Pepe, Antonietta, Bucci, Mariarosaria, Russo, Giulia, Galeone, Aldo
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
Assuntos:
Chemical Biology and Nucleic Acid Chemistry
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7736819/
https://ncbi.nlm.nih.gov/pubmed/33270863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa1109
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