Site-specific replacement of the thymine methyl group by fluorine in thrombin binding aptamer significantly improves structural stability and anticoagulant activity

Here we report investigations, based on circular dichroism, nuclear magnetic resonance spectroscopy, molecular modelling, differential scanning calorimetry and prothrombin time assay, on analogues of the thrombin binding aptamer (TBA) in which individual thymidines were replaced by 5-fluoro-2′-deoxy...

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Vydáno v:Nucleic Acids Res
Hlavní autoři: Virgilio, Antonella, Petraccone, Luigi, Vellecco, Valentina, Bucci, Mariarosaria, Varra, Michela, Irace, Carlo, Santamaria, Rita, Pepe, Antonietta, Mayol, Luciano, Esposito, Veronica, Galeone, Aldo
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2015
Témata:
Chemical Biology and Nucleic Acid Chemistry
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4678827/
https://ncbi.nlm.nih.gov/pubmed/26582916
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv1224
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