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Stability and Binding Properties of a Modified Thrombin Binding Aptamer
Aptamer-based drugs represent an attractive approach in pharmacological therapy. The most studied aptamer, thrombin binding aptamer (TBA), folds into a well-defined quadruplex structure and binds to its target with good specificity and affinity. Modified aptamers with improved biophysical properties...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Biophysical Society
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2157226/ https://ncbi.nlm.nih.gov/pubmed/17890401 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.107.117382 |
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