Thrombin binding aptamer G-quadruplex stabilized by pyrene-modified nucleotides

Guanine-rich regions of the human genome can adopt non-canonical secondary structures. Their role in regulating gene expression has turned them into promising targets for therapeutic intervention. Ligands based on polyaromatic moieties are especially suitable for targeting G-quadruplexes utilizing t...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Nucleic Acids Res
Prif Awduron: Kovačič, Matic, Podbevšek, Peter, Tateishi-Karimata, Hisae, Takahashi, Shuntaro, Sugimoto, Naoki, Plavec, Janez
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Oxford University Press 2020
Pynciau:
Structural Biology
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7144916/
https://ncbi.nlm.nih.gov/pubmed/32095808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa118
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