Conformational Effects in Enzyme Catalysis: Reaction via a High Energy Conformation in Fatty Acid Amide Hydrolase

Quantum mechanics/molecular mechanics and molecular dynamics simulations of fatty acid amide hydrolase show that reaction (amide hydrolysis) occurs via a distinct, high energy conformation. This unusual finding has important implications for fatty acid amide hydrolase, a key enzyme in the endocannab...

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Main Authors: Lodola, Alessio, Mor, Marco, Zurek, Jolanta, Tarzia, Giorgio, Piomelli, Daniele, Harvey, Jeremy N., Mulholland, Adrian J.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Biophysical Society 2007
Ábhair:
Biophysical Letters
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1751413/
https://ncbi.nlm.nih.gov/pubmed/17098788
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.106.098434
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