Steady-state pharmacokinetics of imipenem in febrile neutropenic cancer patients.

We ascertained the pharmacokinetics of imipenem in febrile granulocytopenic cancer patients. The values observed were both different from and significantly more variable than those observed in normal volunteers. Free drug concentrations exceeded the MIC for 90% of Escherichia coli, Klebsiella pneumo...

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Detalhes bibliográficos

Publicado no:	Antimicrob Agents Chemother
Principais autores:	Drusano, G L, Plaisance, K I, Forrest, A, Bustamante, C, Devlin, A, Standiford, H C, Wade, J C
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1987
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC174953/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3479047/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.31.9.1420
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