Steady-state pharmacokinetics of imipenem in febrile neutropenic cancer patients.

We ascertained the pharmacokinetics of imipenem in febrile granulocytopenic cancer patients. The values observed were both different from and significantly more variable than those observed in normal volunteers. Free drug concentrations exceeded the MIC for 90% of Escherichia coli, Klebsiella pneumo...

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發表在:	Antimicrob Agents Chemother
Principais autores:	Drusano, G L, Plaisance, K I, Forrest, A, Bustamante, C, Devlin, A, Standiford, H C, Wade, J C
格式:	Artigo
語言:	Inglês
出版:	American Society for Microbiology (ASM) 1987
主題:	Research Article
在線閱讀:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC174953/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3479047/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.31.9.1420
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