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Local anaesthetic and anti-arrhythmic actions of alprenolol relative to its effect on intracellular potentials and other properties of isolated cardiac muscle

1. Alprenolol, a β-adrenoceptor blocking drug reported to have the same potency as propranolol in vitro and in vivo, was found to be four times more active than procaine as a local anaesthetic on frog sciatic nerve. 2. At doses of 0·125 mg/kg and above alprenolol protected anaesthetized guinea-pigs...

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Detalhes bibliográficos
Main Authors: Singh, B. N., Williams, E. M. Vaughan
Formato: Artigo
Idioma:Inglês
Publicado em: 1970
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1702589/
https://ncbi.nlm.nih.gov/pubmed/4392560
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