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Carbocyclic Pyrimidine Nucleosides as Inhibitors of S-Adenosylhomocysteine Hydrolase
The design, synthesis and unexpected inhibitory activity against S-adenosylhomocysteine hydrolase (SAHase) for a series of truncated carbocyclic pyrimidine nucleoside analogues is presented. Of the four nucleosides obtained, 10 was found to be active with a K(i) value of 5.0 μM against SAHase.
Sparad:
| Huvudupphovsmän: | , , , , , , |
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| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
2006
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1702506/ https://ncbi.nlm.nih.gov/pubmed/16904326 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2006.07.052 |
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