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CARBOCYCLIC THYMIDINE ANALOGUES FOR USE AS POTENTIAL THERAPEUTIC AGENTS

The discovery of azidothymidine’s (AZT) activity against human immunodeficiency virus (HIV) provided strong rationale for the design of additional thymidine analogues. One drawback of many nucleoside analogues is the toxicity that often arises due to phosphorylation by cellular kinases. In order to...

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Detalhes bibliográficos
Main Authors: Seley-Radtke, Katherine L., Sunkara, Naresh K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3701155/
https://ncbi.nlm.nih.gov/pubmed/20183606
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15257770903091920
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