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Carbocyclic Pyrimidine Nucleosides as Inhibitors of S-Adenosylhomocysteine Hydrolase

The design, synthesis and unexpected inhibitory activity against S-adenosylhomocysteine hydrolase (SAHase) for a series of truncated carbocyclic pyrimidine nucleoside analogues is presented. Of the four nucleosides obtained, 10 was found to be active with a K(i) value of 5.0 μM against SAHase.

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書目詳細資料
Main Authors: Mosley, Sylvester L., Bakke, Brian A., Sadler, Joshua M., Sunkara, Naresh K., Kathleen, M. Dorgan, Zhou, Zhaohui Sunny, Seley-Radtke, Katherine L.
格式: Artigo
語言:Inglês
出版: 2006
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC1702506/
https://ncbi.nlm.nih.gov/pubmed/16904326
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2006.07.052
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