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Unfolding and internalization of proteins by the ATP-dependent proteases ClpXP and ClpAP

ClpX and ClpA are molecular chaperones that interact with specific proteins and, together with ClpP, activate their ATP-dependent degradation. The chaperone activity is thought to convert proteins into an extended conformation that can access the sequestered active sites of ClpP. We now show that Cl...

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Auteurs principaux: Singh, Satyendra K., Grimaud, Regis, Hoskins, Joel R., Wickner, Sue, Maurizi, Michael R.
Format: Artigo
Langue:Inglês
Publié: The National Academy of Sciences 2000
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC16793/
https://ncbi.nlm.nih.gov/pubmed/10922052
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