Chirality sensing by Escherichia coli topoisomerase IV and the mechanism of type II topoisomerases

Escherichia coli topoisomerase (Topo) IV is an essential type II Topo that removes DNA entanglements created during DNA replication. Topo IV relaxes (+) supercoils much faster than (–) supercoils, promoting replication while sparing the essential (–) supercoils. Here, we investigate the mechanism un...

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Bibliografiske detaljer
Main Authors: Stone, Michael D., Bryant, Zev, Crisona, Nancy J., Smith, Steven B., Vologodskii, Alexander, Bustamante, Carlos, Cozzarelli, Nicholas R.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2003
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC166367/
https://ncbi.nlm.nih.gov/pubmed/12857958
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1133178100
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