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Chirality sensing by Escherichia coli topoisomerase IV and the mechanism of type II topoisomerases
Escherichia coli topoisomerase (Topo) IV is an essential type II Topo that removes DNA entanglements created during DNA replication. Topo IV relaxes (+) supercoils much faster than (–) supercoils, promoting replication while sparing the essential (–) supercoils. Here, we investigate the mechanism un...
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| Main Authors: | , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2003
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC166367/ https://ncbi.nlm.nih.gov/pubmed/12857958 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1133178100 |
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