Chirality sensing by Escherichia coli topoisomerase IV and the mechanism of type II topoisomerases

Escherichia coli topoisomerase (Topo) IV is an essential type II Topo that removes DNA entanglements created during DNA replication. Topo IV relaxes (+) supercoils much faster than (–) supercoils, promoting replication while sparing the essential (–) supercoils. Here, we investigate the mechanism un...

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Dettagli Bibliografici
Autori principali: Stone, Michael D., Bryant, Zev, Crisona, Nancy J., Smith, Steven B., Vologodskii, Alexander, Bustamante, Carlos, Cozzarelli, Nicholas R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2003
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC166367/
https://ncbi.nlm.nih.gov/pubmed/12857958
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1133178100
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