Chirality sensing by Escherichia coli topoisomerase IV and the mechanism of type II topoisomerases

Escherichia coli topoisomerase (Topo) IV is an essential type II Topo that removes DNA entanglements created during DNA replication. Topo IV relaxes (+) supercoils much faster than (–) supercoils, promoting replication while sparing the essential (–) supercoils. Here, we investigate the mechanism un...

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Publicat a:	Proc Natl Acad Sci U S A
Autors principals:	Stone, Michael D., Bryant, Zev, Crisona, Nancy J., Smith, Steven B., Vologodskii, Alexander, Bustamante, Carlos, Cozzarelli, Nicholas R.
Format:	Artigo
Idioma:	Inglês
Publicat:	National Academy of Sciences 2003
Matèries:	Biological Sciences
Accés en línia:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC166367/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12857958/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.1133178100
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