RNA-binding protein HuR enhances p53 translation in response to ultraviolet light irradiation

Exposure to short-wavelength UV light (UVC) strongly induces p53 expression. In human RKO colorectal carcinoma cells, this increase was not due to elevated p53 mRNA abundance, cytoplasmic export of p53 mRNA, or UVC-triggered stabilization of the p53 protein. Instead, p53 translation was potently enh...

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Hauptverfasser: Mazan-Mamczarz, Krystyna, Galbán, Stefanie, de Silanes, Isabel López, Martindale, Jennifer L., Atasoy, Ulus, Keene, Jack D., Gorospe , Myriam
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2003
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC166233/
https://ncbi.nlm.nih.gov/pubmed/12821781
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1432104100
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