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RNA-binding protein HuR enhances p53 translation in response to ultraviolet light irradiation

Exposure to short-wavelength UV light (UVC) strongly induces p53 expression. In human RKO colorectal carcinoma cells, this increase was not due to elevated p53 mRNA abundance, cytoplasmic export of p53 mRNA, or UVC-triggered stabilization of the p53 protein. Instead, p53 translation was potently enh...

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Published in:Proc Natl Acad Sci U S A
Main Authors: Mazan-Mamczarz, Krystyna, Galbán, Stefanie, de Silanes, Isabel López, Martindale, Jennifer L., Atasoy, Ulus, Keene, Jack D., Gorospe, Myriam
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2003
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC166233/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12821781/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.1432104100
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