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RNA-binding protein HuR enhances p53 translation in response to ultraviolet light irradiation

Exposure to short-wavelength UV light (UVC) strongly induces p53 expression. In human RKO colorectal carcinoma cells, this increase was not due to elevated p53 mRNA abundance, cytoplasmic export of p53 mRNA, or UVC-triggered stabilization of the p53 protein. Instead, p53 translation was potently enh...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Mazan-Mamczarz, Krystyna, Galbán, Stefanie, de Silanes, Isabel López, Martindale, Jennifer L., Atasoy, Ulus, Keene, Jack D., Gorospe, Myriam
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2003
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC166233/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12821781/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.1432104100
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