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Site-specific Arylation of Rat Glutathione S-Transferase A1 and A2 by Bromobenzene Metabolites in vivo

The hepatotoxicity of bromobenzene (BB) derives from its reactive metabolites (epoxides and quinones) which arylate cellular proteins. Application of proteomic methods to liver proteins from rats treated with an hepatotoxic dose of [(14)C]-BB has identified more than 40 target proteins, but no adduc...

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Bibliografiske detaljer
Main Authors: Koen, Yakov M., Yue, Weimin, Galeva, Nadezhda A., Williams, Todd D., Hanzlik, Robert P.
Format: Artigo
Sprog:Inglês
Udgivet: 2006
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1661840/
https://ncbi.nlm.nih.gov/pubmed/17112229
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx060142s
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