Discovery of diverse thyroid hormone receptor antagonists by high-throughput docking

Treatment of hyperthyroidism, a common clinical condition that can have serious manifestations in the elderly, has remained essentially unchanged for >30 years. Directly antagonizing the effect of the thyroid hormone at the receptor level may be a significant improvement for the treatment of hyperth...

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Dades bibliogràfiques

Publicat a:	Proc Natl Acad Sci U S A
Autors principals:	Schapira, Matthieu, Raaka, Bruce M., Das, Sharmistha, Fan, Li, Totrov, Maxim, Zhou, Zhiguo, Wilson, Stephen R., Abagyan, Ruben, Samuels, Herbert H.
Format:	Artigo
Idioma:	Inglês
Publicat:	National Academy of Sciences 2003
Matèries:	Biological Sciences
Accés en línia:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC165879/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12777627/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.1131854100
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