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Discovery of diverse thyroid hormone receptor antagonists by high-throughput docking

Treatment of hyperthyroidism, a common clinical condition that can have serious manifestations in the elderly, has remained essentially unchanged for >30 years. Directly antagonizing the effect of the thyroid hormone at the receptor level may be a significant improvement for the treatment of hype...

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Main Authors: Schapira, Matthieu, Raaka, Bruce M., Das, Sharmistha, Fan, Li, Totrov, Maxim, Zhou, Zhiguo, Wilson, Stephen R., Abagyan, Ruben, Samuels, Herbert H.
Formáid: Artigo
Teanga:Inglês
Foilsithe: National Academy of Sciences 2003
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC165879/
https://ncbi.nlm.nih.gov/pubmed/12777627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1131854100
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