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A ligand-reversible dimerization system for controlling protein–protein interactions

Chemically induced dimerization provides a general way to gain control over intracellular processes. Typically, FK506-binding protein (FKBP) domains are fused to a signaling domain of interest, allowing crosslinking to be initiated by addition of a bivalent FKBP ligand. In the course of protein engi...

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Publicat a:Proc Natl Acad Sci U S A
Autors principals: Rollins, Carl T., Rivera, Victor M., Woolfson, Derek N., Keenan, Terence, Hatada, Marcos, Adams, Susan E., Andrade, Lawrence J., Yaeger, David, van Schravendijk, Marie Rose, Holt, Dennis A., Gilman, Michael, Clackson, Tim
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2000
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC16505/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10852943/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.100101997
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