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A ligand-reversible dimerization system for controlling protein–protein interactions

Chemically induced dimerization provides a general way to gain control over intracellular processes. Typically, FK506-binding protein (FKBP) domains are fused to a signaling domain of interest, allowing crosslinking to be initiated by addition of a bivalent FKBP ligand. In the course of protein engi...

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Збережено в:
Опубліковано в::Proc Natl Acad Sci U S A
Автори: Rollins, Carl T., Rivera, Victor M., Woolfson, Derek N., Keenan, Terence, Hatada, Marcos, Adams, Susan E., Andrade, Lawrence J., Yaeger, David, van Schravendijk, Marie Rose, Holt, Dennis A., Gilman, Michael, Clackson, Tim
Формат: Artigo
Мова:Inglês
Опубліковано: National Academy of Sciences 2000
Предмети:
Biological Sciences
Онлайн доступ:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC16505/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10852943/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.100101997
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