A ligand-reversible dimerization system for controlling protein–protein interactions

Chemically induced dimerization provides a general way to gain control over intracellular processes. Typically, FK506-binding protein (FKBP) domains are fused to a signaling domain of interest, allowing crosslinking to be initiated by addition of a bivalent FKBP ligand. In the course of protein engi...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Rollins, Carl T., Rivera, Victor M., Woolfson, Derek N., Keenan, Terence, Hatada, Marcos, Adams, Susan E., Andrade, Lawrence J., Yaeger, David, van Schravendijk, Marie Rose, Holt, Dennis A., Gilman, Michael, Clackson, Tim
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 2000
Soggetti:	Biological Sciences
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC16505/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10852943/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.100101997
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