A ligand-reversible dimerization system for controlling protein–protein interactions

Chemically induced dimerization provides a general way to gain control over intracellular processes. Typically, FK506-binding protein (FKBP) domains are fused to a signaling domain of interest, allowing crosslinking to be initiated by addition of a bivalent FKBP ligand. In the course of protein engi...

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Hlavní autoři: Rollins, Carl T., Rivera, Victor M., Woolfson, Derek N., Keenan, Terence, Hatada, Marcos, Adams, Susan E., Andrade, Lawrence J., Yaeger, David, van Schravendijk, Marie Rose, Holt, Dennis A., Gilman, Michael, Clackson, Tim
Médium: Artigo
Jazyk:Inglês
Vydáno: The National Academy of Sciences 2000
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC16505/
https://ncbi.nlm.nih.gov/pubmed/10852943
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