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Single-molecule detection of DNA hybridization

We demonstrate the detection of nanometer-scale conformational changes of single DNA oligomers through a micromechanical technique. The quantity monitored is the displacement of a micrometer-size bead tethered to a surface by the probe molecule undergoing the conformational change. This technique al...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Singh-Zocchi, Mukta, Dixit, Sanhita, Ivanov, Vassili, Zocchi, Giovanni
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2003
Fag:
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC164633/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12808129/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.1337215100
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