Multidrug efflux in intrinsic resistance to trimethoprim and sulfamethoxazole in Pseudomonas aeruginosa.

Pseudomonas aeruginosa possesses at least two multiple drug efflux systems which are defined by the outer membrane proteins OprM and OprJ. We have found that mutants overexpressing OprM were two- and eightfold more resistant than their wild-type parent to sulfamethoxazole (SMX) and trimethoprim (TMP...

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Veröffentlicht in:	Antimicrob Agents Chemother
Hauptverfasser:	Köhler, T, Kok, M, Michea-Hamzehpour, M, Plesiat, P, Gotoh, N, Nishino, T, Curty, L K, Pechere, J C
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 1996
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC163521/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9036831/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.40.10.2288
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