Multidrug efflux in intrinsic resistance to trimethoprim and sulfamethoxazole in Pseudomonas aeruginosa.

Pseudomonas aeruginosa possesses at least two multiple drug efflux systems which are defined by the outer membrane proteins OprM and OprJ. We have found that mutants overexpressing OprM were two- and eightfold more resistant than their wild-type parent to sulfamethoxazole (SMX) and trimethoprim (TMP...

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Bibliografiske detaljer

Udgivet i:	Antimicrob Agents Chemother
Principais autores:	Köhler, T, Kok, M, Michea-Hamzehpour, M, Plesiat, P, Gotoh, N, Nishino, T, Curty, L K, Pechere, J C
Format:	Artigo
Sprog:	Inglês
Udgivet:	American Society for Microbiology (ASM) 1996
Fag:	Research Article
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC163521/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9036831/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.40.10.2288
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