Multidrug efflux in intrinsic resistance to trimethoprim and sulfamethoxazole in Pseudomonas aeruginosa.

Pseudomonas aeruginosa possesses at least two multiple drug efflux systems which are defined by the outer membrane proteins OprM and OprJ. We have found that mutants overexpressing OprM were two- and eightfold more resistant than their wild-type parent to sulfamethoxazole (SMX) and trimethoprim (TMP...

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Detalles Bibliográficos

Publicado en:	Antimicrob Agents Chemother
Principais autores:	Köhler, T, Kok, M, Michea-Hamzehpour, M, Plesiat, P, Gotoh, N, Nishino, T, Curty, L K, Pechere, J C
Formato:	Artigo
Idioma:	Inglês
Publicado:	American Society for Microbiology (ASM) 1996
Assuntos:	Research Article
Acceso en liña:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC163521/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9036831/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.40.10.2288
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