Structure of DNA polymerase β with a benzo[c]phenanthrene diol epoxide-adducted template exhibits mutagenic features

We have determined the crystal structure of the human base excision repair enzyme DNA polymerase β (Pol β) in complex with a 1-nt gapped DNA substrate containing a template N(2)-guanine adduct of the tumorigenic (−)-benzo[c]phenanthrene 4R,3S-diol 2S,1R-epoxide in the gap. Nucleotide insertion oppos...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Batra, Vinod K., Shock, David D., Prasad, Rajendra, Beard, William A., Hou, Esther W., Pedersen, Lars C., Sayer, Jane M., Yagi, Haruhiko, Kumar, Subodh, Jerina, Donald M., Wilson, Samuel H.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2006
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1630674/
https://ncbi.nlm.nih.gov/pubmed/17079493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0605069103
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky