Structure of DNA polymerase β with a benzo[c]phenanthrene diol epoxide-adducted template exhibits mutagenic features

We have determined the crystal structure of the human base excision repair enzyme DNA polymerase β (Pol β) in complex with a 1-nt gapped DNA substrate containing a template N(2)-guanine adduct of the tumorigenic (−)-benzo[c]phenanthrene 4R,3S-diol 2S,1R-epoxide in the gap. Nucleotide insertion oppos...

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Bibliographische Detailangaben
Hauptverfasser: Batra, Vinod K., Shock, David D., Prasad, Rajendra, Beard, William A., Hou, Esther W., Pedersen, Lars C., Sayer, Jane M., Yagi, Haruhiko, Kumar, Subodh, Jerina, Donald M., Wilson, Samuel H.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2006
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1630674/
https://ncbi.nlm.nih.gov/pubmed/17079493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0605069103
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