A Ras-induced conformational switch in the Ras activator Son of sevenless

The Ras-specific guanine nucleotide-exchange factors Son of sevenless (Sos) and Ras guanine nucleotide-releasing factor 1 (RasGRF1) transduce extracellular stimuli into Ras activation by catalyzing the exchange of Ras-bound GDP for GTP. A truncated form of RasGRF1 containing only the core catalytic...

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Autores principales: Freedman, Tanya S., Sondermann, Holger, Friedland, Gregory D., Kortemme, Tanja, Bar-Sagi, Dafna, Marqusee, Susan, Kuriyan, John
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2006
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1629002/
https://ncbi.nlm.nih.gov/pubmed/17075039
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0608127103
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