Antigen Processing of the Heptavalent Pneumococcal Conjugate Vaccine Carrier Protein CRM(197) Differs Depending on the Serotype of the Attached Polysaccharide

The pneumococcal (Pn) conjugate vaccine includes seven different polysaccharides (PS) conjugated to CRM(197). Utilizing antigen-processing cells and a CRM(197)-specific mouse T-cell hybridoma, we found that the serotype of conjugated PnPS dramatically affected antigen processing of CRM(197). Unconju...

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Detalhes bibliográficos
Main Authors: Leonard, Ethan G., Canaday, David H., Harding, Clifford V., Schreiber, John R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2003
Assuntos:
Microbial Immunity and Vaccines
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC161992/
https://ncbi.nlm.nih.gov/pubmed/12819115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.71.7.4186-4189.2003
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