Antigen Processing of the Heptavalent Pneumococcal Conjugate Vaccine Carrier Protein CRM(197) Differs Depending on the Serotype of the Attached Polysaccharide

The pneumococcal (Pn) conjugate vaccine includes seven different polysaccharides (PS) conjugated to CRM(197). Utilizing antigen-processing cells and a CRM(197)-specific mouse T-cell hybridoma, we found that the serotype of conjugated PnPS dramatically affected antigen processing of CRM(197). Unconju...

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Hlavní autoři: Leonard, Ethan G., Canaday, David H., Harding, Clifford V., Schreiber, John R.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2003
Témata:
Microbial Immunity and Vaccines
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC161992/
https://ncbi.nlm.nih.gov/pubmed/12819115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.71.7.4186-4189.2003
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