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Antigen Processing of the Heptavalent Pneumococcal Conjugate Vaccine Carrier Protein CRM(197) Differs Depending on the Serotype of the Attached Polysaccharide

The pneumococcal (Pn) conjugate vaccine includes seven different polysaccharides (PS) conjugated to CRM(197). Utilizing antigen-processing cells and a CRM(197)-specific mouse T-cell hybridoma, we found that the serotype of conjugated PnPS dramatically affected antigen processing of CRM(197). Unconju...

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Udgivet i:Infect Immun
Principais autores: Leonard, Ethan G., Canaday, David H., Harding, Clifford V., Schreiber, John R.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2003
Fag:
Microbial Immunity and Vaccines
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC161992/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12819115/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/IAI.71.7.4186-4189.2003
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