Alternate Polypurine Tracts Affect Rous Sarcoma Virus Integration In Vivo

When the endogenous polypurine tract (PPT) of the Rous sarcoma virus (RSV)-derived vector RSVP(A)Z was replaced with alternate retroviral PPTs, the fraction of unintegrated viral DNA with the normal consensus ends significantly decreased and the retention of part of the PPT significantly increased....

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Main Authors: Oh, Jangsuk, Chang, Kevin W., Alvord, W. Gregory, Hughes, Stephen H.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2006
Teme:
Genome Replication and Regulation of Viral Gene Expression
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1617299/
https://ncbi.nlm.nih.gov/pubmed/17005708
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00361-06
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