The Effects of Alternate Polypurine Tracts (PPTs) and Mutations of Sequences Adjacent to the PPT on Viral Replication and Cleavage Specificity of the Rous Sarcoma Virus Reverse Transcriptase

We previously reported that a mutant Rous sarcoma virus (RSV) with an alternate polypurine tract (PPT), DuckHepBFlipPPT, had unexpectedly high titers and that the PPT was miscleaved primarily at one position following a GA dinucleotide by the RNase H of reverse transcriptase (RT). This miscleavage r...

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Bibliographic Details
Main Authors: Chang, Kevin W., Oh, Jangsuk, Alvord, W. Gregory, Hughes, Stephen H.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2008
Subjects:
Genome Replication and Regulation of Viral Gene Expression
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2519663/
https://ncbi.nlm.nih.gov/pubmed/18562520
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00499-08
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