Alternate Polypurine Tracts (PPTs) Affect the Rous Sarcoma Virus RNase H Cleavage Specificity and Reveal a Preferential Cleavage following a GA Dinucleotide Sequence at the PPT-U3 Junction

Retroviral polypurine tracts (PPTs) serve as primers for plus-strand DNA synthesis during reverse transcription. The generation and removal of the PPT primer requires specific cleavages by the RNase H activity of reverse transcriptases; removal of the PPT primer defines the left end of the linear vi...

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Detalhes bibliográficos
Main Authors: Chang, Kevin W., Julias, John G., Alvord, W. Gregory, Oh, Jangsuk, Hughes, Stephen H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2005
Assuntos:
Genome Replication and Regulation of Viral Gene Expression
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1262584/
https://ncbi.nlm.nih.gov/pubmed/16227289
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.79.21.13694-13704.2005
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