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Mutations in the 5′ End of the Human Immunodeficiency Virus Type 1 Polypurine Tract Affect RNase H Cleavage Specificity and Virus Titer

The RNase H activity of retroviral reverse transcriptases (RTs) degrades viral genomic RNA after it has been copied into DNA, removes the tRNA used to initiate negative-strand DNA synthesis, and generates and removes the polypurine tract (PPT) primer used to initiate positive-strand DNA synthesis. T...

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Bibliografiske detaljer
Main Authors: McWilliams, Mary Jane, Julias, John G., Sarafianos, Stefan G., Alvord, W. Gregory, Arnold, Edward, Hughes, Stephen H.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2003
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC224987/
https://ncbi.nlm.nih.gov/pubmed/14512562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.77.20.11150-11157.2003
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