Mutation of Amino Acids in the Connection Domain of Human Immunodeficiency Virus Type 1 Reverse Transcriptase That Contact the Template-Primer Affects RNase H Activity

The crystal structure of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase in a complex with an RNA-DNA template-primer identified amino acids in the connection domain that make specific contacts with the nucleic acid. We analyzed the effects of mutations in these amino acids by usin...

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Detalhes bibliográficos
Main Authors: Julias, John G., McWilliams, Mary Jane, Sarafianos, Stefan G., Alvord, W. Gregory, Arnold, Edward, Hughes, Stephen H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2003
Assuntos:
Replication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC165255/
https://ncbi.nlm.nih.gov/pubmed/12857924
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.77.15.8548-8554.2003
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