Mutation of Amino Acids in the Connection Domain of Human Immunodeficiency Virus Type 1 Reverse Transcriptase That Contact the Template-Primer Affects RNase H Activity

The crystal structure of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase in a complex with an RNA-DNA template-primer identified amino acids in the connection domain that make specific contacts with the nucleic acid. We analyzed the effects of mutations in these amino acids by usin...

Täydet tiedot

Bibliografiset tiedot

Julkaisussa:	J Virol
Päätekijät:	Julias, John G., McWilliams, Mary Jane, Sarafianos, Stefan G., Alvord, W. Gregory, Arnold, Edward, Hughes, Stephen H.
Aineistotyyppi:	Artigo
Kieli:	Inglês
Julkaistu:	American Society for Microbiology (ASM) 2003
Aiheet:	Replication
Linkit:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC165255/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12857924/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.77.15.8548-8554.2003
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