Unique progressive cleavage mechanism of HIV reverse transcriptase RNase H

HIV-1 reverse transcriptase (RT) degrades the plus strand viral RNA genome while synthesizing the minus strand of DNA. Many RNA fragments, including the polypurine tracts, remain annealed to the new DNA. Several RTs are believed to bind after synthesis to degrade all RNA fragments except the polypur...

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Bibliographic Details
Main Authors: Wisniewski, Michele, Balakrishnan, Mini, Palaniappan, C., Fay, Philip J., Bambara, Robert A.
Format: Artigo
Language:Inglês
Published: The National Academy of Sciences 2000
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC17280/
https://ncbi.nlm.nih.gov/pubmed/11035788
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