YADD Mutants of Human Immunodeficiency Virus Type 1 and Moloney Murine Leukemia Virus Reverse Transcriptase Are Resistant to Lamivudine Triphosphate (3TCTP) In Vitro

When human immunodeficiency virus type 1 (HIV-1) is selected for resistance to 3TC, the methionine normally present at position 184 is replaced by valine or isoleucine. Position 184 is the X of the conserved YXDD motif; positions 185 and 186 form part of the triad of aspartic acids at the polymerase...

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Detalhes bibliográficos
Main Authors: Boyer, Paul L., Gao, Hong-Qiang, Clark, Patrick K., Sarafianos, Stefan G., Arnold, Edward, Hughes, Stephen H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2001
Assuntos:
Replication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC114354/
https://ncbi.nlm.nih.gov/pubmed/11413298
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.75.14.6321-6328.2001
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