Mutations in the 5′ End of the Human Immunodeficiency Virus Type 1 Polypurine Tract Affect RNase H Cleavage Specificity and Virus Titer

The RNase H activity of retroviral reverse transcriptases (RTs) degrades viral genomic RNA after it has been copied into DNA, removes the tRNA used to initiate negative-strand DNA synthesis, and generates and removes the polypurine tract (PPT) primer used to initiate positive-strand DNA synthesis. T...

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Detalhes bibliográficos

Publicado no:	J Virol
Principais autores:	McWilliams, Mary Jane, Julias, John G., Sarafianos, Stefan G., Alvord, W. Gregory, Arnold, Edward, Hughes, Stephen H.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 2003
Assuntos:	Replication
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC224987/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14512562/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.77.20.11150-11157.2003
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