Posttranslational hydroxylation of ankyrin repeats in IκB proteins by the hypoxia-inducible factor (HIF) asparaginyl hydroxylase, factor inhibiting HIF (FIH)

Studies on hypoxia-sensitive pathways have revealed a series of Fe(II)-dependent dioxygenases that regulate hypoxia-inducible factor (HIF) by prolyl and asparaginyl hydroxylation. The recognition of these unprecedented signaling processes has led to a search for other substrates of the HIF hydroxyla...

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Главные авторы: Cockman, Matthew E., Lancaster, David E., Stolze, Ineke P., Hewitson, Kirsty S., McDonough, Michael A., Coleman, Mathew L., Coles, Charlotte H., Yu, Xiaohong, Hay, Ronald T., Ley, Steven C., Pugh, Christopher W., Oldham, Neil J., Masson, Norma, Schofield, Christopher J., Ratcliffe, Peter J.
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 2006
Предметы:
Biological Sciences
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC1578504/
https://ncbi.nlm.nih.gov/pubmed/17003112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0606877103
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