Proteomics-based Identification of Novel Factor Inhibiting Hypoxia-inducible Factor (FIH) Substrates Indicates Widespread Asparaginyl Hydroxylation of Ankyrin Repeat Domain-containing Proteins

Post-translational hydroxylation has been considered an unusual modification on intracellular proteins. However, following the recognition that oxygen-sensitive prolyl and asparaginyl hydroxylation are central to the regulation of the transcription factor hypoxia-inducible factor (HIF), interest has...

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Bibliographic Details
Main Authors: Cockman, Matthew E., Webb, James D., Kramer, Holger B., Kessler, Benedikt M., Ratcliffe, Peter J.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2009
Subjects:
Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2649815/
https://ncbi.nlm.nih.gov/pubmed/18936059
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.M800340-MCP200
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