Simultaneous central nervous system distribution and pharmacokinetic–pharmacodynamic modelling of the electroencephalogram effect of norfloxacin administered at a convulsant dose in rats

1. The objective of this study was to investigate the contribution of norfloxacin blood–brain barrier (BBB) transport to its delayed electroencephalogram (EEG) effect in rats. 2. Norfloxacin was injected as a bolus dose of 150 mg kg(−1). Blood samples were collected for total norfloxacin plasma conc...

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Bibliografiske detaljer
Main Authors: Chenel, Marylore, Marchand, Sandrine, Dupuis, Antoine, Lamarche, Isabelle, Paquereau, Joël, Pariat, Claudine, Couet, William
Format: Artigo
Sprog:Inglês
Udgivet: 2004
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Papers
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1574943/
https://ncbi.nlm.nih.gov/pubmed/15155539
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0705748
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