Pharmacokinetic-Pharmacodynamic Modeling of the Electroencephalogram Effect of Norfloxacin in Rats

A previously developed pharmacokinetic-pharmacodynamic (PK-PD) modeling approach was used to investigate the epileptogenic activity of norfloxacin as a representative antibiotic with concentration-dependent antimicrobial activity. Rats received an intravenous infusion of norfloxacin at a rate of 5 m...

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Autores principales: Chenel, Marylore, Barbot, Agnès, Dupuis, Antoine, Mimoz, Olivier, Paquereau, Joël, Bouquet, Serge, Couet, William
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2003
Materias:
Experimental Therapeutics
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC155845/
https://ncbi.nlm.nih.gov/pubmed/12760873
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.47.6.1952-1957.2003
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