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Pharmacokinetic-Pharmacodynamic Modeling of the Electroencephalogram Effect of Imipenem in Healthy Rats
A pharmacokinetic-pharmacodynamic (PK-PD) modeling approach was developed to investigate the epileptogenic activity of imipenem in rats. Initially, animals received an intravenous infusion of imipenem at a rate of 2.65 mg min(−1) for 30 min. Blood samples were collected for drug assay, and an electr...
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| Autores principales: | , , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
American Society for Microbiology
2001
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC90531/ https://ncbi.nlm.nih.gov/pubmed/11353611 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.45.6.1682-1687.2001 |
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