Pharmacokinetic-Pharmacodynamic Modeling of the Electroencephalogram Effect of Imipenem in Healthy Rats
A pharmacokinetic-pharmacodynamic (PK-PD) modeling approach was developed to investigate the epileptogenic activity of imipenem in rats. Initially, animals received an intravenous infusion of imipenem at a rate of 2.65 mg min(−1) for 30 min. Blood samples were collected for drug assay, and an electr...
Zapisane w:
| Wydane w: | Antimicrob Agents Chemother |
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| Główni autorzy: | , , , , , , |
| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
American Society for Microbiology (ASM)
2001
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC90531/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11353611/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.45.6.1682-1687.2001 |
| Etykiety: |
Nie ma etykietki, Dołącz pierwszą etykiete!
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